ICI 182,780 (ICI) protects against estradiol-17ß-d-glucuronide (E17G)-induced impairment of bile flow and biliary secretion of dinitrophenyl-glutathione and taurocholate in the perfused rat liver.

<p>Temporal changes in bile flow (panel A) and in the biliary excretion rate of both total dinitrophenyl-glutathione (DNP-G, panel B) and taurocholate (panel C) throughout the perfusion period. PRLs were treated with a bolus of E17G (3 µmol/liver) or with the E17G vehicle DMSO/BSA 10% in saline (control), in the presence or absence of ICI (0.5 µM). ^a Control significantly different from E17G, ^b Control significantly different from E17G+ICI, ^c E17G significantly different from E17G+ICI. (p<0.05). N = 3–4 animals per group.