Cowpox-encoded CPXV203 subverts antigen presentation by engaging MHCI in the Golgi and subjecting it to KDEL receptor mediated retrieval.

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection

Hansen, Spencer J.
Rushton, John
Dekonenko, Alexander
Chand, Hitendra S.
Olson, Gwyneth K.
Hutt, Julie A.
Pickup, David
Lyons, C. Rick
Lipscomb, Mary F.

April 2011

AbstractOrthopoxviruses encode multiple proteins that modulate host immune responses. We determined ...

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

Luteijn, R.D.
Hoelen, H.
Kruse, E.
van Leeuwen, W.F.
Grootens, J.
Horst, D.
Koorengevel, M.
Drijfhout, J.W.
Kremmer, E.
Früh, K.
Neefjes, J.J.
Killian, A.
Lebbink, R.J.
Ressing, M.E.
Wiertz, E.J.

January 2014

CD8(+) CTLs detect virus-infected cells through recognition of virus-derived peptides presented at t...

Cowpox Virus Genome Encodes a Second Soluble Homologue of Cellular TNF Receptors, Distinct from CrmB, That Binds TNF but Not LTα

Smith, Craig A.
Hu, Fang-Qi
Smith, Terri Davis
Richards, Cheryl L.
Smolak, Pamela
Goodwin, Raymond G.
Pickup, David J.

September 1996

AbstractWe show the cowpox genome (Brighton Red strain) contains a single copy gene,crmC,expressed a...

Structural mechanism of ER retrieval of MHC class I by cowpox.

William H McCoy
Xiaoli Wang
Wayne M Yokoyama
Ted H Hansen
Daved H Fremont

One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility com...

Structural Mechanism of ER Retrieval of MHC Class I by Cowpox

William H. McCoy IV (116342)
Xiaoli Wang (46677)
Wayne M. Yokoyama (116349)
Ted H. Hansen (46681)
Daved H. Fremont (46679)

November 2012

<div><p>One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibi...

Structural Mechanism of ER Retrieval of MHC Class I by

January 2012

One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility com...

Cowpox Virus Exploits the Endoplasmic Reticulum Retention Pathway to Inhibit MHC Class I Transport to the Cell Surface

Byun, Minji
Wang, Xiaoli
Pak, Melissa
Hansen, Ted H.
Yokoyama, Wayne M.

November 2007

SummaryMajor histocompatibility complex (MHC) class I molecules assemble with peptides in the ER lum...

Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation

McCoy IV, William Howard

May 2013

Immunomodulatory proteins that subvert major histocompatibility complex class I: MHCI) antigen prese...

Cowpox Virus Inhibits the Transporter Associated with Antigen Processing to Evade T Cell Recognition

Alzhanova, Dina
Edwards, David M.
Hammarlund, Erika
Scholz, Isabel G.
Horst, Daniëlle
Wagner, Mary J.
Upton, Chris
Wiertz, Emmanuel J.
Slifka, Mark K.
Früh, Klaus

November 2009

SummaryCowpox virus encodes an extensive array of putative immunomodulatory proteins, likely contrib...

CPXV203 co-opts the KDELR to retrieve MHCI from the Golgi.

William H. McCoy IV (116342)
Xiaoli Wang (46677)
Wayne M. Yokoyama (116349)
Ted H. Hansen (46681)
Daved H. Fremont (46679)

November 2012

<p>Comparison of the separate but complementary strategies employed by CPXV012 and CPXV203 to downre...

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells

Spel, Lotte
Luteijn, Rutger D.
Drijfhout, Jan W.
Nierkens, Stefan
Boes, Marianne
Wiertz, Emmanuel J.H.

February 2018

Viruses may interfere with the MHC class I antigen presentation pathway in order to avoid CD8+ T cel...

A negative feedback modulator of antigen processing evolved from a frameshift in the cowpox virus genome

Lin, J
Eggensperger, S
Hank, S
Wycisk, AI
Wieneke, R
Mayerhofer, PU
Tampé, R

January 2014

Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune syst...

A Negative Feedback Modulator of Antigen Processing Evolved from a Frameshift in the Cowpox Virus Genome

Jiacheng Lin
Sabine Eggensperger
Susanne Hank
Agnes I. Wycisk
Ralph Wieneke
Peter U. Mayerhofer

January 2014

Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune syst...

Two Mechanistically Distinct Immune Evasion Proteins of Cowpox Virus Combine to Avoid Antiviral CD8 T Cells

Byun, Minji
Verweij, Marieke C.
Pickup, David J.
Wiertz, Emmanuel J.H.J.
Hansen, Ted H.
Yokoyama, Wayne M.

November 2009

SummaryDownregulation of MHC class I on the cell surface is an immune evasion mechanism shared by ma...

Jenner's Irony: Cowpox Taps into T Cell Evasion

Wilkinson, Gavin W.G.
Lehner, Paul J.

November 2009

CPXV12 is the first poxvirus gene product demonstrated to inhibit the transporter associated with an...

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection

Hansen, Spencer J.
Rushton, John
Dekonenko, Alexander
Chand, Hitendra S.
Olson, Gwyneth K.
Hutt, Julie A.
Pickup, David
Lyons, C. Rick
Lipscomb, Mary F.

April 2011

AbstractOrthopoxviruses encode multiple proteins that modulate host immune responses. We determined ...

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

Luteijn, R.D.
Hoelen, H.
Kruse, E.
van Leeuwen, W.F.
Grootens, J.
Horst, D.
Koorengevel, M.
Drijfhout, J.W.
Kremmer, E.
Früh, K.
Neefjes, J.J.
Killian, A.
Lebbink, R.J.
Ressing, M.E.
Wiertz, E.J.

January 2014

CD8(+) CTLs detect virus-infected cells through recognition of virus-derived peptides presented at t...

Cowpox Virus Genome Encodes a Second Soluble Homologue of Cellular TNF Receptors, Distinct from CrmB, That Binds TNF but Not LTα

Smith, Craig A.
Hu, Fang-Qi
Smith, Terri Davis
Richards, Cheryl L.
Smolak, Pamela
Goodwin, Raymond G.
Pickup, David J.

September 1996

AbstractWe show the cowpox genome (Brighton Red strain) contains a single copy gene,crmC,expressed a...

Structural mechanism of ER retrieval of MHC class I by cowpox.

William H McCoy
Xiaoli Wang
Wayne M Yokoyama
Ted H Hansen
Daved H Fremont

One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility com...

Structural Mechanism of ER Retrieval of MHC Class I by Cowpox

William H. McCoy IV (116342)
Xiaoli Wang (46677)
Wayne M. Yokoyama (116349)
Ted H. Hansen (46681)
Daved H. Fremont (46679)

November 2012

<div><p>One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibi...

Structural Mechanism of ER Retrieval of MHC Class I by

January 2012

One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility com...

Cowpox Virus Exploits the Endoplasmic Reticulum Retention Pathway to Inhibit MHC Class I Transport to the Cell Surface

Byun, Minji
Wang, Xiaoli
Pak, Melissa
Hansen, Ted H.
Yokoyama, Wayne M.

November 2007

SummaryMajor histocompatibility complex (MHC) class I molecules assemble with peptides in the ER lum...

Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation

McCoy IV, William Howard

May 2013

Immunomodulatory proteins that subvert major histocompatibility complex class I: MHCI) antigen prese...

Cowpox Virus Inhibits the Transporter Associated with Antigen Processing to Evade T Cell Recognition

Alzhanova, Dina
Edwards, David M.
Hammarlund, Erika
Scholz, Isabel G.
Horst, Daniëlle
Wagner, Mary J.
Upton, Chris
Wiertz, Emmanuel J.
Slifka, Mark K.
Früh, Klaus

November 2009

SummaryCowpox virus encodes an extensive array of putative immunomodulatory proteins, likely contrib...

CPXV203 co-opts the KDELR to retrieve MHCI from the Golgi.

William H. McCoy IV (116342)
Xiaoli Wang (46677)
Wayne M. Yokoyama (116349)
Ted H. Hansen (46681)
Daved H. Fremont (46679)

November 2012

<p>Comparison of the separate but complementary strategies employed by CPXV012 and CPXV203 to downre...

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells

Spel, Lotte
Luteijn, Rutger D.
Drijfhout, Jan W.
Nierkens, Stefan
Boes, Marianne
Wiertz, Emmanuel J.H.

February 2018

Viruses may interfere with the MHC class I antigen presentation pathway in order to avoid CD8+ T cel...

A negative feedback modulator of antigen processing evolved from a frameshift in the cowpox virus genome

Lin, J
Eggensperger, S
Hank, S
Wycisk, AI
Wieneke, R
Mayerhofer, PU
Tampé, R

January 2014

Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune syst...

A Negative Feedback Modulator of Antigen Processing Evolved from a Frameshift in the Cowpox Virus Genome

Jiacheng Lin
Sabine Eggensperger
Susanne Hank
Agnes I. Wycisk
Ralph Wieneke
Peter U. Mayerhofer

January 2014

Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune syst...

Two Mechanistically Distinct Immune Evasion Proteins of Cowpox Virus Combine to Avoid Antiviral CD8 T Cells

Byun, Minji
Verweij, Marieke C.
Pickup, David J.
Wiertz, Emmanuel J.H.J.
Hansen, Ted H.
Yokoyama, Wayne M.

November 2009

SummaryDownregulation of MHC class I on the cell surface is an immune evasion mechanism shared by ma...

Jenner's Irony: Cowpox Taps into T Cell Evasion

Wilkinson, Gavin W.G.
Lehner, Paul J.

November 2009

CPXV12 is the first poxvirus gene product demonstrated to inhibit the transporter associated with an...

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection

Hansen, Spencer J.
Rushton, John
Dekonenko, Alexander
Chand, Hitendra S.
Olson, Gwyneth K.
Hutt, Julie A.
Pickup, David
Lyons, C. Rick
Lipscomb, Mary F.

April 2011

AbstractOrthopoxviruses encode multiple proteins that modulate host immune responses. We determined ...

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

Luteijn, R.D.
Hoelen, H.
Kruse, E.
van Leeuwen, W.F.
Grootens, J.
Horst, D.
Koorengevel, M.
Drijfhout, J.W.
Kremmer, E.
Früh, K.
Neefjes, J.J.
Killian, A.
Lebbink, R.J.
Ressing, M.E.
Wiertz, E.J.

January 2014

CD8(+) CTLs detect virus-infected cells through recognition of virus-derived peptides presented at t...

Cowpox Virus Genome Encodes a Second Soluble Homologue of Cellular TNF Receptors, Distinct from CrmB, That Binds TNF but Not LTα

Smith, Craig A.
Hu, Fang-Qi
Smith, Terri Davis
Richards, Cheryl L.
Smolak, Pamela
Goodwin, Raymond G.
Pickup, David J.

September 1996

AbstractWe show the cowpox genome (Brighton Red strain) contains a single copy gene,crmC,expressed a...

Cowpox-encoded CPXV203 subverts antigen presentation by engaging MHCI in the Golgi and subjecting it to KDEL receptor mediated retrieval.

Abstract

Extracted data

Cowpox-encoded CPXV203 subverts antigen presentation by engaging MHCI in the Golgi and subjecting it to KDEL receptor mediated retrieval.

Abstract

Extracted data

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