Metabolic Outcomes in Wildtype Male Offspring.

<p>Boxplots showing the smallest observation (lower bar), lower and upper quartile (box), median (line in the box) and largest observation (upper bar) of selected phenotypic markers: <b>a</b>) weight in g, <b>b</b>) fasted, glucose in mmol/L, <b>c</b>) AUC and <b>d</b>) fasted insulin (ng/ml) are given for male offspring of control breedings (open bars), paternal diabetes (longitudinal shading) and maternal diabetes (diagonal shading), at 14 and 26 weeks of age. Mean glucose ± STD during ipGTTs for offspring of maternal diabetes, paternal diabetes and controls are shown for 14 (<b>panel e</b>) and 26 week (<b>panel f</b>) old males. Glucose clearance after ip bolus of glucose (ipGTT) was significantly impaired at all time points for offspring of <b>maternal</b> diabetes, and at 30 and 60 minutes in 14 week old mice, and at 60 minutes after injection in 26 week old offspring of <b>paternal</b> diabetes. * Denotes statistically significant difference vs. control (*p<0.05, ** p<0.01, *** p<0.001).