Multiple alignment of the scallop Tgfbr1 peptide sequence with orthologs from other species.

<p>Identical and similar amino acids are shaded. The signal peptide (SP), transmembrane domain (TM) and serine/threonine kinase domain (KD) are indicated with the solid-line horizontal arrows above the alignment. The ten conserved cysteine residues in the extracellular domain and the GS motif in the kinase domain are indicated with bold and underlined text. The L45 loop is highlighted with the dashed-line arrows under the alignment. The exon-intron junctions within the bivalve (scallop and oyster) <i>Tgfbr1</i> genes are indicated with black arrowheads. The species and the GenBank accession numbers are as follows: <i>C. gigas</i> (CAD20573), <i>D. rerio</i> (ABR20510.1), <i>X. laevis</i> (AAA84997.1), <i>R. norvegicus</i> (AAA83216.1) and <i>H. sapiens</i> (CAF02096.2).