LEDGF/p75 protein domains, gene structure and primate alignment.

<p>LEDGF/p75 functional protein domains (green) with the integrase binding domain (IBD, indicated in red) and the PWWP domain, which regulates chromatin association. LEDGF/p75 spliced RNA with different exons (light and dark purple) is linked to the protein domains. The third line represents the <i>PSIP1</i> gene region with the coding regions (purple) and non coding regions (introns are grey, 5′UTR and 3′UTR are respectively orange and yellow). The location of the discussed SNPs in this work is indicated (red arrows: SNPs detected after screening; blue arrows: 2 tagSNPs in African cohort). The second panel shows the LEDGF/p75 protein alignment of humans and four primate species based on the reference sequences. The integrase binding domain (red box) is indicated, showing no variation in the four primates. PWWP = proline-tryptophan-tryptophan-proline domain; NLS = nuclear localization signal; AT = adenine-thymine rich DNA binding region; IBD = integrase binding domain; UTR = untranslated region.