Modular organization of family B2 DNA polymerases in <i>E. histolytica</i> and structural model of EhDNApolB2.

<p>(<b>A</b>) <i>E. histolytica</i> contains four family B2 DNA polymerases in its genome. These DNA polymerase present a C-terminal region with conserved exonuclease and polymerase motifs characteristic of a family B2 DNA polymerases (green, blue and red boxes). The N-terminal region, indicated by a thin line, presents no similitude to other proteins and is composed of 180 to 500 amino acids. The shortest DNA polymerase is present at loci EHI_018010 and is dubbed EhDNApolB2 throughout this work (<b>B</b>) Homology structural model of EhDNApolB2. The 3′–5′ exonuclease domain is shown in green and the 5′–3′ polymerization domain is shown in blue. The extended TPR2 motif is shown in red encircling double stranded DNA (yellow colored).