Cell size and NANOG profiles from simulation of hESCs with blocked division.

<p>(A) The cell size and (B) NANOG expression are shown for hESCs at t = 0 (blue curves) and after 16 hr (red curves) according to the PBE model with blocked division. Corresponding density plots for (C) size and (D) NANOG are also shown. The density function scale is represented by the color bar. Plots were generated a total of 10,000 hESCs. (E) Model prediction of the fraction of hESCs in LN and HN regions right before and after 16 hr of blocking cell division. Regions are defined as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050715#pone-0050715-g004" target="_blank">Figure 4</a> and results are shown as mean ± std.dev. from three simulations with different random number generator seeds.