Expression of 5′ and 3′ TPGs.

<p><b>A</b>: Average expression in hematological tissues of 5′ and 3′ TPGs compared to expression of all RefSeq genes (all genes) and a subset of genes known to be expressed in hematological tissue (H/S genes, according to UniProt database). <b>B</b>: Expression of TPGs in hematopoietic tissues (HEM) compared to non-hematopoietic tissues of epithelial (EPI) and mesenchymal (MES) origin. <b>C</b>: Expression difference between 5′ TPGs and 3′ TPGs in various samples of hematopoietic origin from two datasets (D1 and D2, see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002797#s4" target="_blank">Methods</a>): bone marrow (BM), peripheral blood mononuclear cells (PBMC), spleen (SPL), T-cells (T), lymph node (LN) and tonsil (TNSL). All differences are highly significant (###). <b>D</b>: Difference in expression of 5′TPG between GM128 cell line (of lymphoid origin) and K562 cell line (of myeloid origin) for translocations reported in cells of lymphoid (HEM-L) and myeloid (HEM-M) origin. Higher value means more expression in GM128 compared to K562. Differences are significant in both groups, as indicated by Wilcoxon test. ***, **, *, ns: P<0.001, 0.01, 0.05, Mann-Whitney U test. ###, ##, ns: P<0.001, P<0.01, non-significant, Wilcoxon signed rank test.