Endocrine measurements in BACHD×LepR-cre offspring.

<p>Circulating levels of leptin and insulin were measured in 6-month old female mice from the second breeding (n = 9–10/genotype). (A) Both BACHD and BACHD/LepR-cre showed elevated leptin levels but no significant differences between BACHD and BACHD/LepR-cre could be detected. (B) Only BACHD mice displayed significantly higher insulin levels than wt mice. However, no significant differences could be detected between BACHD and BACHD/LepR-cre. All data are expressed as means ± SEM. Significant differences from WT and/or LepR-cre mice: * p<0.05 (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051168#pone.0051168.s002" target="_blank">Statistical Results S1</a>).