Effects of MPO inhibition on HDL transporting cholesterol and leukocyte adhesion/rolling flux.

<p>A. Effects of MPO inhibition on HDL transporting cholesterol from J774 macrophage cells into medium. *<i>P</i><0.05, compared with control group. Data are mean± S.E.M. of 5–8 experiments from different mice. B. Representative images of adherent leukocytes in the cremasteric microcirculation (cells with arrow heads indicate adherent monocytes, cells without arrow heads indicate rolling leukocytes) via intra-vital microscopy in C57BL/6 mice with different treatment. a, blank control group; b, INV-315treated control; c, TNFα-treated group; d, TNFα-treated groups with INV-315 pretreatment. C and D, Leukocyte adhesion and leukocyte rolling flux in cremasteric microcirculation via intra-vital microscopy in C57BL/6 mice with different treatment. #<i>P</i><0.05 compared with TNFα treated group. Data are mean ± SD of 5 different mice, 5–10 experiments from each animal.