Molecular modelling of the <i>Myo7a^I487N/I487N ewaso</i> mutation.

<p>(<b>A</b>) Partial ribbon representation of a 3D model of myosin V 2DFS highlighting the Ile⁴⁸⁷ amino acid residue, which is localised to the hinge region between the head and tail domains of the protein. (<b>B</b>) Schematic diagram showing superimposed images of the hinge region (<i>Myo7a^+/+</i> in red and the <i>Myo7a^I487N/I487N ewaso</i> mutation in blue) after 4 ns of molecular dynamics simulation showing a conformational change in the hinge region close to the Ile⁴⁸⁷ mutation site, showing the involvement of residues 670–673 around the hinge region causing the distortion.