DAPT inhibits the increase of wall thickness in cultured vascular strips from PH rats.

<p>(A–D) Verhoeff iron hematocylin staining of Pulmonary artery vascular strips (×400): (A) pulmonary artery in culturing lung tissue strip treated with additional equivalent M199; (B) pulmonary artery in culturing lung tissue strip treated with DMSO; (C) pulmonary artery in culturing lung tissue strip treated with DAPT (1 µmol/l); (D) pulmonary artery in culturing lung tissue strip treated with DAPT (10 µmol/l). (E) the change of vascular media thickness of hypoxia rats with or without DAPT treating. The vascular media of hypoxia rats treated with DAPT were significantly thinner than those treated with M199 or DMSO. (*, P<0.05 compared to control group. Data are expressed as means ± s.e.m.)