Schematic diagram of Myo7a protein structure showing the location of <i>Myo7a^I487N/I487N ewaso</i> and <i>Myo7a^F947I/F947I dumbo</i> mutations (in red) in relation to reported <i>shaker</i> mutations.

<p>DFNA11/DFNB2/USH1B human mutations within close proximity to a reported <i>shaker</i> mutation are shown in parentheses <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051284#pone.0051284-Weston1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051284#pone.0051284-Bharadwaj1" target="_blank">[56]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051284#pone.0051284-Jaijo1" target="_blank">[57]</a>. Details of these mouse mutations are included in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051284#pone-0051284-t001" target="_blank">Table 1</a>. IQ, isoleucine-glutamine motif; CC1, Coiled Coil domain; MyTH4, Myosin Tail Homology 4; SH3, SRC Homology 3 domain.