The mutation spectra of double loss-of-function isolates induced by APOBEC3G.

<p>(A) The reporter gene region of 28 Can^R Ade⁻ isolates obtained from <i>UNG1</i> cells expressing APOBEC3G was sequenced. 41.7% of mutations were C to T transitions, while 46.9% were C to G transversions. (B) Similarly, the reporter gene region of 33 Can^R Ade⁻ isolates obtained from <i>ung1Δ</i> cells expressing APOBEC3G was sequenced. All mutations were C to T transitions. <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003149#pgen.1003149.s007" target="_blank">Table S3</a> lists APOBEC3G-induced mutations, while <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003149#pgen.1003149.s009" target="_blank">Table S5</a> lists mutations found in empty vector controls.