Pathway to show how Mcl-1, a member of the Bcl-2 family, influences apoptosis.

<p>(<b>A</b>) The intrinsic (mitochondrial) cell death pathway is controlled by the Bcl-2 protein family, including BH3-only proteins, anti-apoptotic Bcl-2 proteins, Bax, Bak and Bid. (<b>B</b>) The <i>Mcl-1</i> gene consists of three exons; the anti-apoptotic Mcl-1_L and the pro-apoptotic Mcl-1_S protein isoforms result from inclusion and skipping of exon 2 (open box), respectively.