<i>SLC22A1</i> and <i>ABCB1</i> haplotypes association with imatinib pharmacokinetics in Asian patients with CML (n = 38).
- Onkar Singh (110457)
- Jason Yongsheng Chan (110458)
- Keegan Lin (110460)
- Charles Chuah Thuan Heng (110463)
- Balram Chowbay (110465)
Publication date
December 2012
DOIAbstract
<p><i>SLC22A1 and ABCB1</i> haplotypes were stratified according to specific combination haplotype profiles and associations were checked with imatinib (A) clearance, CL and (B) trough concentration, C<sub>0h</sub>. A trend towards low clearance and high C<sub>0h</sub> was observed from S<sub>low</sub>-A<sub>low</sub>, S<sub>low</sub>-A<sub>high</sub>, S<sub>high</sub>-A<sub>low</sub> to S<sub>high</sub>-A<sub>high</sub>. The simultaneous possession of S<sub>low</sub> with A<sub>low</sub> was associated with a 73.2% higher clearance and 41.2% lower trough concentration than patients carrying other haplotype combinations.</p
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