Observed overlap of the genomic regions bound by the TF Twi and its co-regulators.

<p>A-C: The observed overlap (blue bar) between genomic regions bound by Twi and genomic regions bound by its known co-regulator Snail and its candidate co-regulator Ase is depicted in comparison to the expected random overlap (red curve). The overlap of genomic regions bound by Twi in stage 10 to 11 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052055#pone.0052055-Zinzen1" target="_blank">[6]</a> with the genomic regions bound by Twi/Snail/Dorsal in stage 5–7 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052055#pone.0052055-Zeitlinger1" target="_blank">[28]</a> (A), Snail (stage 10 to 11 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052055#pone.0052055-Southall1" target="_blank">[7]</a>) (B) and Ase (stage 10 to 11 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052055#pone.0052055-Southall1" target="_blank">[7]</a>) (C) is shown. A’-C’: Distribution and overlap (red) of Twi- and Twi/Snail/Dorsal- (A’), Twi- and Snail- (B’) and Twi- and Ase- (C’), bound genomic regions. The regions bound by Twi are shown in blue, the regions bound by the co-regulatory TFs in green and the overlapping regions bound by both Twi and the co-regulatory TFs in red.