AR and FGF19 gene expression show a positive correlation in human HCC tissue samples and are associated with poor patient prognosis.

<p>Gene expression data was obtained for <i>AR</i> and <i>FGF19</i> from two independent microarray studies and correlation of expression levels was analyzed as described in Methods. (A) <i>AR</i> and <i>FGF19</i> gene expression values were obtained from the GSE1898 dataset (90 HCC tissue samples) and showed a significant positive correlation r = 0.18, <i>P</i><0.05. (B) AR and FGF19 gene expression values were obtained from the GSE5975 dataset (238 HCC tissue samples) and showed a positive correlation r = 0.25, <i>P</i><0.0001. (C) <i>AR</i> and <i>FGF19</i> gene expression in the subclasses of tumors corresponding to patients with poor and better survival originally identified in the GSE1898 dataset. ***<i>P</i> = 0.0005, **<i>P</i> = 0.0068.