Introducing Ligand-Based Hydrogen Bond Donors to a Receptor: Both Selectivity and Binding Affinity for Anion Recognition in Water Can Be Improved

Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of <b>Zn3</b>–ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many metalloenzymes