Single i.p. injection of IDB increases platelet counts and megakaryocyte content even when administered 24 hours after irradiation.

<p>Groups of BALB/c mice (N = 10/group/time point) were injected with a single i.p. dose of IDB (1080 µg/kg body weight) 24 hours after irradiation with 6 Gy. At 2 weeks, mice were euthanized and blood platelet counts (<b>A</b>) were performed and tissue for histologic examination for megakaryocyte content of bone marrow (<b>B</b>) and spleen (<b>C</b>) were obtained. Megakaryocyte baseline values were determined on 5 untreated mice, euthanized to obtain spleens and bone marrows for histologic examination.