The set of multi-analyte prognostic modules identified by the MAPIT algorithm.

<p>Ten eModules (<i>A–J</i>) and three mModules (<i>K–M</i>) are shown. Node colour represents gene expression change of LTS patients compared to STS patients. Red, down-regulation; Green, up-regulation. Shade is proportional to the −log (p-value) of the change. Node border colour represents DNA methylation change of LTS patients compared to STS patients. Red, hypomethylation; Green, hypermethylation. Shade is proportional to the −log (p-value) of the change. Diamond nodes, genes reported to bear somatic mutations in GBM patients. Rectangular nodes, genes identified as GBM prognostic markers in either <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052973#pone.0052973-Colman1" target="_blank">[4]</a> or <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052973#pone.0052973-Noushmehr1" target="_blank">[6]</a>. Hexagonal nodes, genes both reported to bear somatic mutations and identified as prognostic markers in either <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052973#pone.0052973-Colman1" target="_blank">[4]</a> or <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052973#pone.0052973-Noushmehr1" target="_blank">[6]</a>. Purple star: genes located in CNV regions identified in GBM patients <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052973#pone.0052973-The1" target="_blank">[37]</a>. Edge, protein-protein interaction. Edge width is proportional to the combined significance of expression changes of the two involved nodes (see Methods for details).