Accelerated deterioration of skeletal muscle in <i>BubR1</i>^+/GTTA mice.

<p>(A) Incidence and latency of lordokyphosis. A log rank test was used for statistical analysis: <i>***P<0.001</i>. (B) Mean fiber diameter of gastrocnemius (Gastro), abdominal (ABD), and paraspinal muscles of 15-month-old mice. (C) Expression of the senescence markers <i>p16</i>^Ink4a and <i>p19</i>^Arf in gastrocnemius muscles of 15 month-old mice analyzed by qRT-PCR. (D–F) Treadmill exercise ability of 3- and 15-month-old mice: presented are running time (D), distance travelled (E), and workload (F) performed. Error bars represent SEM. Males mice were used for all analysis in D–F: wildtype 3 months, n = 3 males; <i>BubR1</i>^+/GTTA 3 months, n = 5 males, wildtype and <i>BubR1</i>^+/GTTA 15 months, n = 4 males each. An unpaired t-test was used for statistical analyses in (B–F): *<i>P<0.05</i>.