Correlation between bacterial metabolites production and AP1 activity.

<p>A) Bacterial phyla distribution in healthy human and in our selected bacterial collection. Inner part of the cycle represents the phyla distribution in our collection, outer part was based on the latest data from Tap et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052869#pone.0052869-Tap1" target="_blank">[60]</a>. B) PCA showing the correlation between bacterial phyla, acid production and activation of AP-1 pathway. A positive correlation is observed for Firmicutes (violet) and Fusobacteria (pink). Bacteroidetes (orange), Actinobacteria (green). C) A detailed analysis using a three dimensional plot confirms the strong positive correlation between Butyrate (violet circles) producing bacteria and induction of AP-1 response and shows that no positive correlation is observed for propionate producing bacteria (orange circles) and non butyrate/propionate producing bacteria (black circles). Bacteria producing both butyrate and propionate are presented with yellow circles. AP-1 response (log RLU), propionate and butyrate concentration in (mM).