Blunted induction of lipogenic gene expression and lipogenesis in LS-PGC-1β^−/− mice in response to fasting-refeeding.

<p>The graphs depict the expression of glycolytic and lipogenic gene expression in WT and LS-PGC-1β^−/− mice given either fasted 40 h or fasted 24 h and then refed for 16 h with high sucrose diet (n = 6). Representative western blots for corresponding proteins in same mice are shown. *P<0.05 versus WT mice of the same treatment group. The graphs depict the rates of glycolysis, fatty acid synthesis, and palmitate oxidation in hepatocytes from WT and LS-PGC-1β^−/− mice after 24 h fasting and then refeeding for 16 h with high sucrose diet. *P<0.05 versus WT mice.