GDC-0941 inhibits tumor growth and increases DOX-mediated effects on caspase 3 activity.

<p><b>A)</b> Inhibition of RD tumor growth (in %) in nude mice treated with 1.2 mg/kg DOX (i.p. every third day for 22 days; n = 19), 75 mg/kg GDC-0941 (orally every day for 22 days; n = 9), the combination of both drugs (n = 12) at the time points indicated. Vehicle-treated animals served a controls (n = 18). <b>B)</b> Caspase 3 positive cells (in %) in tumors of nude mice isolated after 22 days of treatment with DOX and/or GDC-0941 or solvent. Data represent mean+SEM. *<i>P</i><0.05 by ANOVA/Tukey’s testing.