GABAergic interneurogenesis in the hilus is sex-dependent in aged apoE-KI mice.

<p><b><i>A</i></b>, Total numbers of BrdU and GABA double-positive cells in the hilus of female and male apoE-KI mice at 16 months of age were determined 1 month after BrdU injection. Values are mean ± SE (n = 6−8 mice per group). *<i>p</i><0.05 in 16-month-old male apoE4-KI mice compared to their female counterparts (<i>post-hoc</i> Bonferroni test); **<i>p</i><0.01 in older male apoE3-KI mice compared to their female counterparts at the same age (<i>post-hoc</i> Bonferroni test). <b><i>B, D</i></b>, Images of the hilus of 16-month-old male apoE3-KI mice stained with anti-BrdU (red) and anti-GABA (green) collected 1 month after BrdU injection (magnification: <b><i>B</i></b>, 100x; <b><i>D</i></b>, 200x). <b><i>C, E</i></b>, Images of the hilus of 16-month-old male apoE4-KI mice stained with anti-BrdU (red) and anti-GABA (green) collected 1 month after BrdU injection (magnification: <b><i>C</i></b>, 100x; <b><i>E</i></b>, 200x).