Renal histopathology of<b>Hpt</b>/+ and +/+ female mice at 1, 4, and 52 weeks of age.

<p>Representative glomeruli from <i>Hpt/</i>+ and +/+mice, at 1 week, 4 weeks, and 52 weeks of age. There are no marked histopathological changes between <i>Hpt</i>/+ and +/+ glomeruli at 1 week of age. At 4 weeks of age, <i>Hpt</i>/+ glomeruli show enlargement, diffuse mesangial matrix expansion (D) and a few dilated glomerular capillaries (arrowheads). At 12 months of age, <i>Hpt</i>/+ glomeruli show diffuse (D) and nodular (N) mesangial matrix expansion with mesangiolysis (L), capillary aneurysms (arrowheads), and thickening of glomerular (long arrows) and capsular (short arrows) basement membranes. Hematoxylin and Eosin (H&E), Periodic Acid Schiff (PAS), Jones Methenamine Silver (JMS) stains, and type IV collagen immunohistochemistry are shown; x600.