Chromatin organization at genomic region around Whey Acidic Protein gene (Wap).

<p>Summary of markers of chromatin organization aligned to the Wap region in mouse genome assembly mm9 in the UCSC Genome Browser. (<b>A–B</b>) ChIP-seq reads for H3K4me2 in liver tissue (<b>Liver</b>, red), lactating mammary gland (<b>Lactating MG</b>, blue) and mammary epithelial cells isolated from 12 week virgin mammary glands (<b>Virgin MEC</b>, black). <b>ECR</b>: genomic locations of DHS conserved in mouse and rabbit <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053270#pone.0053270-Millot1" target="_blank">[17]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053270#pone.0053270-Millot2" target="_blank">[54]</a>, CpG island is indicated by dark green bar. (<b>B</b>) Close-up of Wap region from (<b>A</b>). <b>H3Ac</b>: Summary of H3Ac-ChIP results for Wap promoter and HSS2 (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053270#pone.0053270.s003" target="_blank">Fig. S3</a>) in lactating mammary gland (<b>Lact</b>, blue) and Liver tissue (<b>liver</b>, red): closed rectangle indicates enrichment of H3Ac at site, open rectangle indicates lack of enrichment at site. <b>DHS</b>: Summary of DHS results for rabbit from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053270#pone.0053270-Millot1" target="_blank">[17]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053270#pone.0053270-Millot2" target="_blank">[54]</a>. Closed rectangle indicates presence of DHS, open rectangle indicates absence of DHS.