Filtering and highlighting a PPI subnetwork related to phosphorylation in Alzheimer's disease.

<p>A PPI network was generated as explained in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002860#pcbi-1002860-g003" target="_blank">Figure 3</a> starting with 8 genes relevant for Alzheimer's disease (AD) and phosphorylation. (<b>A</b>) The PPI network contains 727 interactions. (<b>B</b>) Filtering for interactions between partners that are housekeeping or expressed in the brain (“whole brain” and “prefrontal cortex”), relate to the GO term “cell death”, and with experimental scores above 0.5, results in a much more focused subnetwork involving 6 of the 8 genes used as input (octagonal nodes). Nodes corresponding to receptors and transcription factors are colored (blue and pink nodes, respectively). Edge directed path analysis from receptors to transcription factors resulted in the association of directionality to some of the edges (arrows). The path LRP6-GSK3B-MAPT-AATF is highlighted in green and described in the text.