Effect of amantadine treatment on motor behaviour.

<p>Three different doses of amantadine were acutely injected together with L-DOPA and a significant antidyskinetic effect was observed at the 10 mg/kg dose (A). Ethovision analysis of the total distance travelled (TDT) shows there is no effect on locomotor activity of either dose of amantadine tested (B). Sub-chronic 5-day treatment with 10 mg/kg amantadine further confirms the antidyskinetic efficacy of the compound (C) and the lack of significant effect on locomotor activity compared to vehicle treatment (D). Data are presented as mean ± s.e.m. Unpaired Student <i>t</i> test (*, p<0.05).