Effect of a delayed acute treatment with IRC-082451 on locomotor activity.

<p>A single dose of 5 mg/kg of IRC was given 2 hours before administration of L-DOPA and the total number of dyskinesias and distance travelled on the same day are presented. A significant reduction in LID count was observed (A) together with an increase in spontaneous distance travelled (B) compared to the same animals under vehicle treatment. Data are presented as mean ± s.e.m. Unpaired Student <i>t</i> test (**, p<0.01).