Effect of a 4-day treatment with IRC-082451 (5 mg/kg/day).

<p>The sub-chronic treatment was given concomitantly with L-DOPA for 4 days and animals were filmed on the 5^th day (A). Total number of dyskinesias (B) and total distance travelled (C) over 6 h of film are presented and a significant reduction in LID counts is observed. Data are expressed as mean ± s.e.m. Unpaired Student <i>t</i> test (**, p<0.01).