Histological characterization of the nigrostriatal dopaminergic pathway in the all primate brains.

<p>Left column: representative coronal sections of healthy (CTRL, A), parkinsonian (MPTP, C), dyskinetic vehicle-treated (VEH, E) and dyskinetic IRC-treated (IRC, G) primate brains stained for tyrosine hydroxylase. Right column: areas of the substantia nigra where stereological counts were performed drawn on representative samples for each group of animals (B, CTRL; D, MPTP; F, VEH; H, IRC). Lower panel: histogram displaying TH-positive neuron number in the substantia nigra (I). Data are expressed as mean cell counts ± s.e.m. Unpaired Student <i>t</i> test (**, p<0.01).