The changing pattern of molecular networks under allele-specific context determined by LD blocks.

<p>(A) Hierarchical clustering on the perturbed interactions based on the association matrix between blocks and their perturbing interactions in PPI, PDI, KPI, and EEI networks, respectively, in which rows represent blocks and columns represent interactions. In each of the four sub-matrices, blocks associated with less than ten interactions are filtered out. The columns are reordered according to hierarchical clustering. The rows colored correspond to B20. (B) The allele-specific sub-network associated with B20. The sub-network is composed of 142 PPIs, 54 PDIs, 93 KPIs, and 26 EEIs, which are marked with green, red, blue and orange, respectively. Nodes marked with red are proteins constituting a GO cellular component (nuclear lumen), and PPIs among these genes are regulated by B20. Nodes marked with green are enzymes from a KEGG pathway (DNA-directed RNA polymerase activity), and their EEIs are regulated by B20.