Autophagy and FoxO1 expression are upregulated during regression of cardiac hypertrophy.

<p>Control C57BL/6 and Tg-GFP-LC3 mice were subjected to sham, 1W TAC and 1W DeTAC surgeries. A) Representative immunoblots of autophagy markers and FoxO1 from mouse hearts. B) Densitometric analyses. C) Representative images of fluorescent LC3 puncta in hearts from Tg-GFP-LC3 mice. Arrows indicate LC3 puncta. D) Mean number of GFP-LC3 dots/cell. Data represent means from at least 3 mice each. * p<0.05, ** p<0.01.