Synthesis of target piperazine derivatives 13a–d and 17.
- Tao Liu (10785)
- Zhiyong Weng (107276)
- Xiaowu Dong (107278)
- Linjie Chen (107280)
- Ling Ma (107282)
- Shan Cen (107285)
- Naiming Zhou (107287)
- Yongzhou Hu (107289)
Publication date
January 2013
DOIAbstract
<p>Reagents and conditions: a) 2-(4-chlorophenyl)acetonitrile, K<sub>2</sub>CO<sub>3</sub>, DMSO, reflux, 18<b> </b>h; b) 4-cyanobenzoyl chloride, Et<sub>3</sub>N, CH<sub>2</sub>Cl<sub>2</sub>, rt, 3<b> </b>h; c) 4-(chloromethyl)benzonitrile, THF, reflux, 2.5<b> </b>h; d) NaBH(OAc)<sub>3</sub>, CH<sub>2</sub>Cl<sub>2</sub>, rt, 12<b> </b>h; e) 4-fluorobenzoyl chloride, Et<sub>3</sub>N, CH<sub>2</sub>Cl<sub>2</sub>, rt, 3<b> </b>h; f) EDC.HCl, CH<sub>2</sub>Cl<sub>2</sub>, rt, 8<b> </b>h; g) 1-bromo-3-chloropropane, KI, CH<sub>3</sub>CN, MWI, 15<b> </b>min; h) 4-fluorobenzoyl chloride, Et<sub>3</sub>N, CH<sub>2</sub>Cl<sub>2</sub>, 0°C, 5<b> </b>h; i) KI, K<sub>2</sub>CO<sub>3</sub>, CH<sub>3</sub>CN, reflux, 24<b> </b>h.</p
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