CAN displacement causes epidermal phenotypes that require signaling by specific Wnts and that resemble phenotypes caused by mutations in the Wnt-binding Ror/CAM-1 receptor.

a<p>Vulval fates: number of vulval progenitor cells adopting vulval fates. Wild-type is 3.00.</p>b<p><i>n</i>: number of animals assayed.</p>c<p><i>p-</i>Values were calculated using a two-tailed Student's <i>t</i> test.</p>d<p>Mixed-stage animals were heat-shocked at 33°C for 45 min and scored 16 h later.</p>e<p>Control animals were of the same genotype as the transgenic animals, but lacked the extrachromosomal transgenic array.</p><p><i>lf</i>, loss-of-function.