Spreading of aberrant methylation to neighboring probesets in the ABC samples.

<p>(A) A schematic representation of how the genome was divided into blocks of genes to study spreading of altered DNA methylation. (B–C) Analysis of spreading of aberrant methylation within genomic neighborhoods. Loci “<i>i</i>” represent probesets that are significantly hypo- (black) or hyper-methylated (grey) in lymphoma samples compared to normal tissues, and loci “<i>i</i>±<i>j</i>” represent both the (<i>i</i>+<i>j</i>)-th and (<i>i</i>−<i>j</i>)-th neighbors of those probesets. For instance, when we focused on probeset #10 (i.e. <i>i</i> = 10), we analyzed spreading of aberrant methylation at probesets #5, 6, 7, 8, 9, 11, 12, 13, 14 and 15. Panel B displays the change in methylation states while panel C shows the change in IQR (variability between samples).