Overview of fold changes of miRNAs versus a measure of statistical significance.

<p>The volcano plot shows the -log₁₀ (p-value) on the y-axis and the fold change (log₂) on the x-axis. A cut-off [-log₁₀ (p-value) = 1.86] was considered to determine differentially expressed miRNAs between diseased and health (control) animals. Seven miRNAs i.e. rno-miR-146b, -132, -21, -503, -199a-5p, -214 and -34a were found to be significantly up-regulated in diseased animals with a fold change ≥0.5 with significant p-value ≤0.01.