Whole-brain functional networks in CN, MCI, and AD.

<p>The first row displays the correlation matrices obtained from partial correlation coefficients (indicated by color bar, range from −1.0 to 1.0) between 90 regions of interests controlling for age, education and gender. The second row displays binary matrices thresholded at a fixed density 15%. The third row illustrates the corresponding brain connectivity graph from the binary matrices. Brain connectivity graphs were visualized using the BrainNet viewer (NKLCNL, Beijing Normal University). Abbreviations for the regions are expanded in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053922#pone-0053922-t001" target="_blank">Table 1</a>. CN = cognitively normal; MCI = mild cognitive impairment; AD = Alzheimer’s disease.