AD- and MCI- related alterations in small-world parameters. A.

<p>The clustering coefficients (<i>C_p</i>) from cognitively normal (CN, black dotted line), mild cognitive impairment (MCI, blue line) and Alzheimer’s disease (AD, red line). *<i>p</i><0.05 for CN vs. MCI (significant at density of 19%∼40%).; ^†<i>p</i><0.05 for CN vs. AD (significant at 19%∼26%, and 32%∼40%); ^‡p<0.05 for MCI vs. AD (significant at 11%∼12%, 17%∼19% and 22%∼23%). <b>B.</b> The <i>L_p</i> from CN, MCI and AD. *<i>p</i><0.05 for MCI vs. AD (significant at 13%, 23%, and 25%∼26%). <b>C.</b> The <i>C_p</i> from AD with clinical dementia rating (CDR) 0.5 (AD_very mild, orange line), and AD with CDR 1.0 (AD_mild, purple line). *<i>p</i><0.05 for AD_very mild vs. AD_mild (significant at 18%∼38%). <b>D.</b> The <i>L_p</i> from AD_very mild and AD_mild. *<i>p</i><0.05 for AD_very mild vs. AD_mild (significant at 11%∼39%).