AD- and MCI -related alterations in hub regions.

<p>Hubs were visualized using the BrainNet viewer (NKLCNL, Beijing Normal University). Purple circle indicates the regions where both Alzheimer’s disease (AD) and mild cognitive impairment (MCI) networks showed decreased betweenness centrality compared with cognitively normal (CN). Red circle indicates the regions where AD network additionally showed decreased betweenness centrality compared with CN. Blue circle indicates the regions where MCI network additionally showed decreased betweenness centraility compared with CN. Abbreviations for the regions are expanded in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053922#pone-0053922-t001" target="_blank">Table 1</a>. L = left; R = right.