Left: Average number of Hydrogen bonds of solvent water with base atoms a) N3-H b) O2 and c) O4 or N4H2 in case of thymine or cytosine, respectively, as a function of the base flip angle.

<p>Right: Solvent accessible surface area of base atoms d) N3-H e) O2 and f) O4 or N4H2 in case of thymine or cytosine, respectively, as a function of the base flip angle. Data from the simulation of the C:G and T:A pairs are plotted in black and green, respectively, data for the T:G mispair is shown in red. For atom labels see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053305#pone-0053305-g002" target="_blank">Figure 2</a>.