<p>A: mRNA level of 5-HT<sub>2C</sub>R was significantly higher in pancreatic islets of db/db mice compared to control mice. B: Protein level of 5-HT<sub>2C</sub>R was significantly higher in pancreatic islets of db/db mice compared to control mice. C: Relative protein level of 5-HT<sub>2C</sub>R. Graphs are shown as a ratio of 5-HT<sub>2C</sub>R to β-actin and compared to controls. All bands were normalized as percentages of the control values. Shown are representative results (average of duplicates) of at least three independent experiments. (<sup>**</sup><i>P</i><0.01).</p
<p>Pancreatic islets were isolated from NOD mice at 4, 8, and 12 weeks of age. 12/15-LO expression w...
<p>(A) 8-OHdG staining (x 200). (B) Measurement of 8-OHdG positive nuclei (%) in the pancreatic isle...
<p>(A) Immunofluorescent staining of insulin and glucagon in mice at ages shown. Glucagon-positive c...
<p>Relative gene expression levels in the islets isolated before (<b>A</b>) and after 5-week HFD fee...
<p>Representative images of pancreas section stained for Ki67 of control group (A) and HFD-PBS (B), ...
<p>(A) H&E staining of islets in pancreatic sections. Bars: 1 mm. (B) The percentage of three islet ...
<p>Representative images of pancreas section stained for glucagon of control group (A) and HFD-PBS (...
<p>Values represent mean ± SEM of copy number adjusted by β-actin expression per 100 ng of cDNA obta...
<p>(A) Tph1, (B) Tph2 mRNA levels and (C) serotonin contents in islets from control mice (GR<sup>Lox...
<p>Proteins from ND, LDR and HDR islets were probed with an antibody against total PKCε (T-PKCε) and...
<p>(A). Representative Western blots (panel 1,3) and PCR analyzes (panel 2,4) of AIF expression in i...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p>Representative images of pancreas section stained for caspase-3 of control group (A) and HFD-PBS ...
<p>Islets were isolated from NL-2 knockout (KO) and wild-type (WT) mice (white bars, WT; black bars,...
<p>Values represent mean ± SEM of copy number adjusted by normalization factor (NF) per 100 ng of cD...
<p>Pancreatic islets were isolated from NOD mice at 4, 8, and 12 weeks of age. 12/15-LO expression w...
<p>(A) 8-OHdG staining (x 200). (B) Measurement of 8-OHdG positive nuclei (%) in the pancreatic isle...
<p>(A) Immunofluorescent staining of insulin and glucagon in mice at ages shown. Glucagon-positive c...
<p>Relative gene expression levels in the islets isolated before (<b>A</b>) and after 5-week HFD fee...
<p>Representative images of pancreas section stained for Ki67 of control group (A) and HFD-PBS (B), ...
<p>(A) H&E staining of islets in pancreatic sections. Bars: 1 mm. (B) The percentage of three islet ...
<p>Representative images of pancreas section stained for glucagon of control group (A) and HFD-PBS (...
<p>Values represent mean ± SEM of copy number adjusted by β-actin expression per 100 ng of cDNA obta...
<p>(A) Tph1, (B) Tph2 mRNA levels and (C) serotonin contents in islets from control mice (GR<sup>Lox...
<p>Proteins from ND, LDR and HDR islets were probed with an antibody against total PKCε (T-PKCε) and...
<p>(A). Representative Western blots (panel 1,3) and PCR analyzes (panel 2,4) of AIF expression in i...
<p>Images show immuno-stainings for insulin (<b>A</b>, <b>B</b>), glucagon (<b>C</b>, <b>D</b>), and...
<p>Representative images of pancreas section stained for caspase-3 of control group (A) and HFD-PBS ...
<p>Islets were isolated from NL-2 knockout (KO) and wild-type (WT) mice (white bars, WT; black bars,...
<p>Values represent mean ± SEM of copy number adjusted by normalization factor (NF) per 100 ng of cD...
<p>Pancreatic islets were isolated from NOD mice at 4, 8, and 12 weeks of age. 12/15-LO expression w...
<p>(A) 8-OHdG staining (x 200). (B) Measurement of 8-OHdG positive nuclei (%) in the pancreatic isle...
<p>(A) Immunofluorescent staining of insulin and glucagon in mice at ages shown. Glucagon-positive c...