Cellular physiological parameters during time course simulation of 0.8M NaCl stress responses in wild type cells with or without the calcineurin inhibitor, FK506.

<p>(<b>A</b>) Intracellular K⁺ (black lines) and Na⁺ (red lines) concentrations in untreated (solid lines) and FK506 treated cells (dashed lines). (<b>B</b>) K⁺ (black lines) and Na⁺ (red lines) influx in untreated (solid lines) and FK506 treated cells (dashed lines). (<b>C</b>) K⁺ (black lines) and Na⁺ (red lines) efflux in untreated (solid lines) and FK506 treated cells (dashed lines). (<b>D</b>) Cell volume (orange lines) and <i>ENA1</i> expression (light blue lines) in wild type cells without (solid lines) and with FK506 (dashed lines). Addition of FK506 does not have any effect on cell volume. (<b>E</b>) Intracellular pH in wild type cells without (solid) and with FK506 (dashed). (<b>F</b>) Membrane potentials in wild type cells without (solid) and with FK506 (dashed). External baseline Na⁺ and K⁺ concentrations are 5 mM, 1 mM, respectively, and the baseline external pH is 6.5.