Functional connectivity disruption in schizophrenic subjects vs controls.

<p>(a) Probability of finding a network link as a function of the Euclidean distance between the nodes (in millimeters): schizophrenics (red) show reduced connectivity than controls (blue) for distances in the middle range (10 to 150 mm). (b) Disruption of <i>global</i> inter-hemispheric connectivity. For each subject, we compute the fraction of links spanning both hemispheres over the total number of links, and plot a normalized histogram over all subjects in each group (normal - blue, schizophrenic - red). (c) Disruption of <i>task-dependent</i> inter-hemispheric connectivity between specific ROIs (Brodmann Area 22 selected bilaterally). The ROIs were defined by a 9 mm radius ball centered at [x = −42, y = −24, z = 3] and [x = 42, y = −24, z = 3]. For each subject, we compute the fraction of links connecting the bilateral ROIs over all links, and show a histogram of this connectivity measure over all subjects in each group. The histograms are similarly normalized.