Comparison of model fits to media transfer experiments of Mothersill et al [19] and Zhang et al [32].

<p>In Mothersill et al (a), the model (solid line) is able to reflect the onset of signalling-induced cell killing seen in a media-transfer experiment as a function of exposure time (circle). For Zhang et al (b-e), the model’s predictions (lines) are compared to observed mutation rates when the number of cells exposed to ionising radiation (b), the level of media dilution before media transfer (c), the amount of time the recipient cells are exposed to the donor media (d) or the amount of time before the donor media was harvested (e) was varied. Good agreement with the overall trends is found in all cases, with the exception of the small plateau in cell number dilution, which suggests some additional complexity in signal production at reduced cell densities.