Prognostic significance assessed using Kaplan-Meier analysis and log-rank tests.

<p>(<b>A, B</b>) The patients with an ICC with high Capn4 expression had a poorer prognosis in terms of overall survival and cumulative recurrence. (<b>C, D</b>) High Capn4 expression had prognostic significance in both subgroups (CA19-9≥37 <i>vs</i>. <37 ng/mL). (<b>E, F, G, H</b>) Capn4, rather than larger diameter, multiple tumors or vascular invasion, stratified patients with N1 disease (lymphatic metastasis) into discrete prognostic groups.