Low miR-150 serum concentrations are associated with an impaired prognosis of critically ill patients.

<p>(A) Long-term surviving patients had higher serum miR-150 levels on admittance to ICU (P = 0.009, U-test) compared to patients that died during long term follow up which displayed significantly lower miR-150 levels. Box plot are displayed, where the bold line indicates the median per group, the box represents 50% of the values, and horizontal lines show minimum and maximum values of the calculated non-outlier values. (B) ROC curve analyses revealed a high prognostic accuracy of miR-150 for overall survival compared to the APACHE-II-score. (C) Kaplan-Meier curve analysis of ICU patients revealing that patients with miR-150 concentrations within the lower quartile had an increased overall mortality as compared to patients with miR-150 serum concentrations of highest quartile. P-values for the Cox regression analysis are given in the figure. (D) Kaplan-Meier survival curves of ICU patients showed that patients with low miR-150 concentrations had an increased overall mortality in the long-term follow-up compared to patients with higher miR-150 levels. ** P<0.01.