<p>Platelet surface coverage increases with increasing VWF plasma levels at all wall shear rates. For each shear rate, bars represent the average platelet surface coverage in each quartile of VWF levels in a cohort of normal donors (n = 50).</p
<p>(A) Purified plasma VWF (2 µg/mL) was incubated with GrB (100 nM), GrM (100 nM), or buffer only i...
<p>A: Curves of thrombin generation obtained in a typical experiment with the plasma of a healthy do...
Thrombus formation under high fluid shear rates at the site of atherosclerotic plaque rupture leads ...
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the ini...
<p>Recalcified citrated whole blood was perfused over type I collagen for 5 min and platelet accumul...
Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboemboli...
shear exposure, but that factor Va release from the -granules is a secondary event and largely the ...
<p>Overview of the main results: changes in closure times after addition of either recombinant vWF o...
Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Wi...
Von Willebrand factor (vWF) is a large multimeric protein found in plasma, intracellular stores of p...
Physical and biochemical forces convert platelets in human blood in vivo from the quiescent state as...
Twelve infusions of plasma concentrates of von Willebrand factor (vWF) were given to four patients w...
<p>Plasma (A) and platelet (B) VWF multimers were assessed by 1.6% SDS-agarose gel electrophoresis a...
<p>Histogram of percent surface coverage (SC) for 150 s<sup>−1</sup> (A), 300 s<sup>−1</sup> (B), 75...
Microfluidic flow assays (MFA) that measure shear dependent platelet function have potential clinica...
<p>(A) Purified plasma VWF (2 µg/mL) was incubated with GrB (100 nM), GrM (100 nM), or buffer only i...
<p>A: Curves of thrombin generation obtained in a typical experiment with the plasma of a healthy do...
Thrombus formation under high fluid shear rates at the site of atherosclerotic plaque rupture leads ...
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the ini...
<p>Recalcified citrated whole blood was perfused over type I collagen for 5 min and platelet accumul...
Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboemboli...
shear exposure, but that factor Va release from the -granules is a secondary event and largely the ...
<p>Overview of the main results: changes in closure times after addition of either recombinant vWF o...
Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Wi...
Von Willebrand factor (vWF) is a large multimeric protein found in plasma, intracellular stores of p...
Physical and biochemical forces convert platelets in human blood in vivo from the quiescent state as...
Twelve infusions of plasma concentrates of von Willebrand factor (vWF) were given to four patients w...
<p>Plasma (A) and platelet (B) VWF multimers were assessed by 1.6% SDS-agarose gel electrophoresis a...
<p>Histogram of percent surface coverage (SC) for 150 s<sup>−1</sup> (A), 300 s<sup>−1</sup> (B), 75...
Microfluidic flow assays (MFA) that measure shear dependent platelet function have potential clinica...
<p>(A) Purified plasma VWF (2 µg/mL) was incubated with GrB (100 nM), GrM (100 nM), or buffer only i...
<p>A: Curves of thrombin generation obtained in a typical experiment with the plasma of a healthy do...
Thrombus formation under high fluid shear rates at the site of atherosclerotic plaque rupture leads ...